Fecal microbiota transplantation for indolent T-cell lymphoproliferative disorder of gastrointestinal tract: A case report and review of literature
Abstract
BACKGROUND
Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract (ITLPD-GI) is a rare clonal T-cell proliferation characterized by chronic diarrhea, abdominal pain, and weight loss. Its non-specific clinical and endoscopic presentation often leads to misdiagnosis as inflammatory bowel disease. Fecal microbiota transplantation (FMT), which aims to restore gut microbial homeostasis, has demonstrated efficacy in recurrent Clostridioides difficile infections, and its immunomodulatory potential is being explored in other conditions. However, the role of the gut microbiome in the pathogenesis of ITLPD-GI remains unknown.
CASE SUMMARY
A male patient presented with recurrent oral ulcers, chronic diarrhea, and significant weight loss. He was initially diagnosed with and treated for ulcerative colitis, without a successful response. A comprehensive re-evaluation, including systematic histopathological and immunohistochemical analyses of mucosal biopsies, confirmed a definitive diagnosis of ITLPD-GI. Following this diagnosis, the patient underwent a series of FMT procedures via colonoscopy. This intervention resulted in a remarkable and sustained clinical remission, with the complete resolution of diarrhea and oral ulcers, and significant weight gain. Follow-up endoscopy demonstrated substantial mucosal improvement, with a marked reduction in previous congestion and edema. The patient reported a significant improvement in his quality of life.
CONCLUSION
This report…
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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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