Causal Relationship between Gut Microbiota, Derived Metabolites, and Diffuse Large B-Cell Lymphoma: A Two-Sample Mendelian Randomization Study
Abstract
Introduction: The human gastrointestinal tract contains approximately one hundred trillion microorganisms that provide numerous benefits, including energy absorption, protection against pathogens, and regulation of the immune system. Alterations in the gut microbiota, known as dysbiosis, can disrupt these normal physiological processes and have been associated with adverse conditions such as inflammatory states, immune dysregulation, and even malignancies. Studies have shown that the gut microbiota of patients with diffuse large B-cell lymphoma (DLBCL) differs significantly from that of healthy individuals, and changes in the abundance of specific gut microbiota contributes to the prognosis of DLBCL patients. Certain microbiota could regulate the development of DLBCL through their metabolites. However, these case-control studies are susceptible to confounding factors such as age, environment, lifestyle, other diseases, and treatments, which may bias the results. Herein, we employ Mendelian randomization (MR) to investigate the causal relationships between gut microbiota, derived metabolites, and DLBCL.
Methods: Gut microbiota data were sourced from the MiBioGen consortium, metabolite information from the TwinsUK and KORA studies, and DLBCL-related data from FinnGen. The single nucleotide polymorphisms (SNPs) were used to serve as instrumental variables (IVs). The primary method for our MR analysis was inverse-variance weighting, enhanced by MR-Egger regression, weighted…
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Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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