AB0176 genetic evidence revealed a causal role of GUT microbiota in polymyalgia rheumatica
Abstract
Polymyalgia rheumatica (PMR) is an inflammatory disease characterized by bilateral pain involving and less commonly the neck and the pelvic girdle[1]. However, no definitive evidence supports that gut microbiota is associated with PMR.In this study, we conducted Mendelian randomization (MR) to assess the associations of genera of gut microbiota with PMR.The data of gut microbiota were derived from the Integrated Epidemiology Unit (IEU) GWAS database, which included 1523 PMR cases and 213145 healthy controls[2]. A series of results were calculated to analyze the causal effects between gut microbiota and PMR. Inverse variance weighted is the primary and we did several analyses to prove MR result, weighted-median, MR Egger regression, and MR-presso. Cochran’s Q statistics were used to quantify the heterogeneity of instrumental variables[3].The MR results for the causal effect of gut microbiota on PMR showed that genus Erysipelatoclostridium(odds ratio (OR)=0.910, 95% confidence interval (CI) =0.307-2.39, p =0.867) and genus Ruminococcaceae(OR=0.394, 95% CI =0.124-1.250, p =0.145) are protective factors for PMR. And genus Butyricimonas(OR=2.837, 95% CI=0.861-9.346, p=0.114), genus Eisenbergiella(OR=1.5818551, 95% CI =0.251-9.945,p=0.631), genus Coprobacter(OR=1.359, 95% CI =0.470-3.925, p =0.586)were correlated with the risk of PMR. In the meantime, heterogeneity(P>0.05) and pleiotropy (P>0.05) analysis confirmed the reliability of MR results.(Figure 1)These findings provided…
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