The Relationship between Canine Behavioral Disorders and Gut Microbiome and Future Therapeutic Perspectives
Abstract
Simple Summary Canine behavioral disorders have become one of the most common concerns and challenging issues among dog owners. Therefore, to face this challenge, searching for novel therapeutic methods is highly required. Accumulated data show that mammals’ gut microbiome, immune system, and nervous system are in continuous communication and influence animal physiology and behavior. This review aimed to summarize and discuss the most important scientific pieces of evidence on the relationship between mental disorders and gut microbiota in dogs, simultaneously presenting comparable outcomes in humans and rodent models. A comprehensive overview of crucial mechanisms of the gut–brain axis is included. Additionally, the possible effects of the fecal microbiome transplantation procedure as a new tool to manipulate gut microbiota are discussed. Abstract Canine behavioral disorders have become one of the most common concerns and challenging issues among dog owners. Thus, there is a great demand for knowledge about various factors affecting dogs’ emotions and well-being. Among them, the gut–brain axis seems to be particularly interesting, especially since in many instances the standard treatment or behavioral therapies insufficiently improve animal behavior. Therefore, to face this challenge, the search for novel therapeutic methods is highly required. Existing data show that mammals’ gut microbiome, immune system, and nervous system are in continuous communication and influence…
How strong is the evidence?
Evidence Hub reads this as a review, done in animal, not in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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