Treatment Patterns and Clinical Outcomes in Children with Stenotrophomonas maltophilia Infections
Abstract
Stenotrophomonas maltophilia is an opportunistic, multidrug-resistant pathogen commonly associated with respiratory and bloodstream infections. Owing to extensive intrinsic and acquired antimicrobial resistance and limited pediatric-specific evidence, contemporary management relies heavily on extrapolation from adult data, underscoring the need to better characterize real-world treatment practices and outcomes in children. This was a retrospective, observational cohort that included hospitalized patients S. maltophilia culture who received active antimicrobial therapy, excluding cases determined by the treating provider to represent colonization. Outcomes assessed included in-hospital mortality, adverse drug effects, and clinical success rates using descriptive statistics. Forty pediatric patients (median [IQR] age of 2.7 [0.7-7.9] years) were included. Respiratory infections accounted for 77.5% of cases, and sulfamethoxazole-trimethoprim monotherapy was the most common treatment regimen (70.0%). Five patients (12.5%) experienced in-hospital mortality, three patients (7.5%) experienced adverse effects related to treatment, and all patients exhibited clinical success. Larger, multicenter observational and prospective studies are warranted to strengthen evidence-based therapeutic approaches for pediatric patients with S. maltophilia infections.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Photochemical behavior of levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.