Clinicomicrobiological profile of patients with Stenotrophomonas maltophilia infections
Abstract
Introduction: Stenotrophomonas maltophilia is an emerging nosocomial pathogen associated with severe infections in critically ill patients and limited therapeutic options due to intrinsic antimicrobial resistance. Indian data describing its clinical spectrum, resistance patterns, and outcomes remain scarce.
Methods: A retrospective observational study was conducted at a tertiary care center in northern India between January 2021-June 2022. Adult patients (≥18 years) with culture-confirmed S. maltophilia infection were included. Only hospital-acquired infections were included. Data on demographics, comorbidities, clinical severity (SOFA, APACHE II), prior antibiotic exposure, and ICU parameters were collected. Microbiological details (source, susceptibility per CLSI guidelines), treatment regimens, resistance profiles, and clinical outcomes (14-day cure, oxygen/vasopressor requirement, mortality) were analyzed.
Results: Among 53 patients with Stenotrophomonas maltophilia isolates, 38 (71.7%) had true infections. Median age was 33.5 years (IQR 26-51.5); 68.4% were male. Bloodstream infection was most common (73.7%), followed by hospital/ventilator-associated pneumonia (26.3%). Diabetes (31.6%) and chronic kidney disease (23.7%) were the main comorbidities. Prior carbapenem (63.2%) and glycopeptide (42.1%) use was frequent. Susceptibility remained high to minocycline (86.8%), levofloxacin (86.8%), and cotrimoxazole (84.2%). Pneumonia, higher SOFA scores, vasopressor use, and…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 53 participants or records.
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