FRI0374 the risk of infection by tumor necrosis factor inhibitors and its associated factors in patients with ankylosing spondylitis: result from korean national health insurance data
Abstract
Background Tumor necrosis factor inhibitors (TNFi) are effective in patients who do not respond to non-steroidal anti-inflammatory drugs, or disease modifying anti-rheumatic drugs, and have been widely used in patients with ankylosing spondylitis (AS). However, there is some evidence that treatment with TNFi can increase the risk of infection in patients with AS. Objectives The aim of this study was to investigate the risk of infection in patients with AS treated with TNFi. Methods Data was obtained from insurance claims database of the Health Insurance Review & Assessment Service (HIRA) in South Korea. Patients who have been prescribed a TNFi such as etanercept (ETN), adalimumab (ADA), golimumab (GLM), and infliximab (IFX) to treat AS from 1 July 2012 to 30 June 2017 were enrolled. We evaluated the incidence rate (IR) and hazard ratio (HR) of serious infections including pneumonia, tuberculosis, and herpes zoster in each TNFi treatment group by using cox proportional hazard model. We further analyzed the HR of infection by sex. Results A total of 2,515 patients were included in the study, and they were prescribed ETN (n=528), ADA (n=914), GLM (n=628), or IFX (n=445). The IRs of serious infection were 1668.63, 1489.88, 1457.58, and 1399.16 per 1,000 person years (pys) in ETN, ADA, GLM, and IFX treated groups, respectively. There was no significant difference in HR of serious infection between the TNFi groups. In the subgroup analysis of major infections, there was no…
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.