Clinical significance of nosocomial Cryptococcus laurentii in urine: A case series
Abstract
To the Editor—The genus Cryptococcus spp comprises ~70 species,1 of which the C. neoformans–C. gattii complex are considered pathogenic. However, non-neoformans cryptococci, such as Cryptococcus laurentii and Cryptococcus albidus, are emerging as opportunistic pathogens, causing disease in patients with impaired cell-mediated immunity (eg, HIV-infected patients or those with hematologic malignancies), in those using steroids or chemotherapeutic agents, and in those with invasive devices.2 Cryptococcus laurentii has been isolated from several sources such as Norway spruce trees (Picea abies) and trembling aspen trees (Populus tremuloides), bird droppings, and perihospital areas.3 Human infections due to C. laurentii have been described as causing fungemia, central nervous system infection, skin and soft-tissue infections, and pneumonia, among others.2 The finding of yeasts in a urine culture of asymptomatic patients is considered colonization. Recent guidelines suggest that the treatment of asymptomatic candiduria consists of eliminating risk factors such as indwelling catheters and witholding treatment except in patients with risk factors for dissemination (eg, neutropenic patients, very-low-birth-weight infants, and prior to urologic procedures).4 Regarding non-neoformans cryptococcuria, the information is lacking; therefore, we aimed to describe a case series about the clinical characteristics and outcomes of hospitalized patients with in-hospital isolation of C. laurentii…
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