Multidrug resistance and inappropriate empiric therapy as predictors of hospital stay in diabetic foot infections
Abstract
Objectives: This study explored the causative pathogens, resistance patterns, and treatment appropriateness for diabetic foot infections (DFI) at a tertiary care center in Jordan.
Methods: A retrospective review was conducted on 234 patients diagnosed with DFIs at a tertiary care center in Jordan. Data collected included patient demographics, diabetes history, infection severity, culture results, and antibiotic treatment details. Bacterial isolates were classified as multidrug-resistant (MDR) or non-MDR based on standard definitions. Therapy was considered appropriate if at least one antibiotic given within the first 48 hours of admission covered all identified pathogens and was administered with the correct dosage, formulation, and route. Statistical analyses examined the relationship between resistance patterns, treatment adequacy, and hospital stay duration.
Results: The most frequently isolated bacterium was Staphylococcus aureus, identified in 117 cases (50.0%), including MRSA (n = 46, 19.6%) and MSSA (n = 71, 30.3%). This was followed by Escherichia coli in 33 cases (14.1%) and Pseudomonas aeruginosa in 32 cases (13.7%). MDR organisms accounted for 152 infections (65%). Empiric therapy was deemed appropriate in 111 patients (47.4%), inappropriate in 74 (31.6%), and not assessable due to missing data in 49 (20.9%). Following culture and susceptibility results, antibiotics in 87 cases (37.2%) remained unchanged. In multivariate analysis, only infection severity was…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 234 participants or records.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.