Epidemiology and prognostic factors of necrotizing fasciitis in resource-limited regions based on 119 cases
Abstract
Necrotizing fasciitis (NF) is a rare, life-threatening soft tissue infection with high amputation and mortality rates, often due to delayed diagnosis and treatment. This study analyzes the clinical characteristics and prognostic factors of NF to improve treatment strategies. A retrospective study was conducted on 119 NF patients treated at a tertiary hospital in Guangxi, China, from 2017 to 2023. Data on demographics, laboratory parameters, microbiology, treatments, and outcomes were collected and analyzed. Comparisons were made between survivors and non-survivors, and between patients with and without amputation. The predictive performance of the Laboratory Risk Indicator for Necrotizing Fasciitis (LRINEC) was assessed using receiver operating characteristic (ROC) curve analysis. Among 119 patients, the mean age was 56.7 years with a male-to-female ratio of 5.3:1. The lower extremities were most commonly affected (58.8%), and diabetes was prevalent (62.3%). Gram-negative bacteria were predominant (62.7%), particularly Escherichia coli (21.6%) and Klebsiella pneumoniae (19.4%), while Gram-positive bacteria were led by Staphylococcus aureus (14.9%). The overall antibiotic resistance rate was 18.7%, with Gram-negatives bacteria highly susceptible to ertapenem, imipenem, and piperacillin-tazobactam, and Gram-positives bacteria to vancomycin and levofloxacin. Amputation and in-hospital mortality rates were 16.8% and 11.8%, respectively. Risk factors for amputation encompassed…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 119 participants or records.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Photochemical behavior of levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.