261. Alternative Antibiotic Prescribing for Community Acquired Pneumonia (CAP) in Pediatric Patients in Relation to Allergy Status
Abstract
Abstract Background While 10% of the population may report a penicillin (PCN) allergy, it has been shown that 90% of these patients are not allergic and may still be able to take PCN safely. Inaccurate reporting of a PCN allergy may lead to prescription of other non-B-lactam or broader spectrum antibiotics. Inpatients with reported antibiotic allergy status have been shown to have inappropriate antibiotic prescribing, increase microbiologic resistance, and suboptimal patient outcomes. Our goal was to evaluate antibiotic prescribing patterns for children with CAP in the setting of reported antibiotic allergy. Methods The Children’s Hospital’s Initiative for Research in Pneumonia (CHIRP) study enrolled inpatient and outpatient children ≥2 months to 18 years of age with a diagnosis of CAP from six participating sites. Demographic data, allergy status, antimicrobial therapy, and clinical outcomes were collected. Overall prevalence of reported antibiotic allergy and alternative therapy used in setting of reported allergy were analyzed. Results A total of 470 subjects were included, enrolled from October 2015 to December 2017. The mean age was 6.3 years (range: 3 months to 18.9 years), 45% were females. Sixty-three (13.4%) subjects self-reported one or more antibiotic allergies. Twenty-seven subjects reported amoxicillin (AMOX) allergy, nine with PCN allergy, nine with amox/clavulanate (AMOX/CLAV) allergy, and 11 with ampicillin (AMP) or ampicillin/sulbactam allergy. Cephalosporin…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 470 participants or records.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.