2337. Clinical Characteristics of Children Infected With Macrolide-Resistant Mycoplasma Pneumonia in Central Ohio—Preliminary Data
Abstract
Abstract Background Macrolide-resistant Mycoplasma pneumoniae (MRMp) has emerged in the last 2 decades, with rates as high as 93% in Asia. Rates in the United Stated vary from 3.5 to 13.2%. By sequencing we identified our local resistance rate of 1.8% (9/477) in isolates collected from October 2015 to December 2017. Previous reports described increased morbidity in patients with MRMp. We evaluated the clinical characteristics of children infected with MRMp in Central Ohio. Methods Of the 9 MRMp isolates identified, clinical data were available in 7 cases. We performed a case–control (1:3) analysis, where Mp patients were matched by month and year of presentation. Retrospective analysis of electronic health records (HER) was performed to identify clinical and treatment characteristics. Continuous variables are shown as medians and inter-quartile ranges (IQR), and categorical variables as percentages. For comparisons T, Mann–Whitney U, and Fisher’s exact tests were used as appropriate. Results Both groups had similar demographics with no differences in age and gender. Median age (IQR) was 8.5 years (6–17) for the MRMp and 8 (IQR 3.5–11.5) for the Macrolide-susceptible Mp (MSMp). Duration of symptoms at presentation was similar, median (IQR) of 11 (4–14) days for MRMp, and 8 (6.25–13.25) days for MSMp (P = 0.7). All patients with MRMp had fever compared with 17 (81%) of the MSMp (P = 0.07). Tmax was similar in both groups (P = 0.11). All patients (100%) had cough. There were no…
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