Laboratory survey of antibiotic nonsusceptibility among Streptococcus pneumoniae isolates in South Carolina, 1998 versus 2000
Abstract
BACKGROUND: In 1998, the South Carolina Department of Health and Environmental Control surveyed clinical microbiology laboratories statewide to determine the prevalence of antibiotic nonsusceptibility among isolates of Streptococcus pneumoniae. A follow-up study was conducted in 2001.
METHODS: A cross-sectional study was conducted to estimate the prevalence of penicillin nonsusceptibility (PCN-N), extended-spectrum cephalosporin nonsusceptibility (ESC-N), and levofloxacin nonsusceptibility (LEV-N) in South Carolina. A standardized questionnaire was mailed to 89 laboratories.
RESULTS: The prevalence of penicillin intermediate resistance increased from 1998 (17.6%) to 2000 (20.9%, chi2 P = 0.008). Furthermore, the prevalence of PCN-N increased from 1998 (34.5%) to 2000 (38.4%, chi2 P = 0.01). The prevalence of ECN-N decreased from 1998 (19.1%) to 2000 (17.7%), but the difference was not significant (chi2 P = 0.25).
CONCLUSION: The laboratory survey was a low-cost method of estimating the change in prevalence of antibiotic nonsusceptibility, and it emphasizes regional surveillance because the prevalence of antibiotic nonsusceptibility varied geographically.
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Photochemical behavior of levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.