Family psittacosis cluster diagnosed by metagenomic next-generation sequencing in Hangzhou City, Eastern China: A case series
Abstract
Rationale: Psittacosis, a human infection caused by Chlamydia psittaci (C psittaci), is often underdiagnosed due to its nonspecific presentation and the limitations of conventional diagnostic methods. This diagnostic challenge can lead to missed outbreaks and delays in appropriate treatment. This report aims to highlight the critical role of metagenomic next-generation sequencing (mNGS) in rapidly identifying C psittaci and facilitating the investigation of a family cluster, thereby providing a clearer rationale for its application in similar scenarios.
Patient concerns: In this study, we report a family cluster of psittacosis cases. All affected individuals had a history of direct or indirect contact with backyard poultry during a visit to a rural village before symptom onset. The index case (Case 1) presented with fever and chills and was subsequently hospitalized. The 2 secondary cases (Cases 2 and 3) exhibited similar clinical manifestations and were treated at the same hospital, where doctors promptly collected specimens for testing based on their shared medical history.
Diagnoses: The diagnosis of C psittaci pneumonia was confirmed by mNGS analysis of bronchoalveolar lavage fluid obtained from 3 patients through bronchoscopy.
Interventions: Combination therapy involving intravenous moxifloxacin and doxycycline was administered for the treatment of infectious pneumonia.
Outcomes: Following timely diagnosis and targeted antimicrobial therapy, all 3 patients attained full…
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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