Risk factors of ventilator-associated pneumonia in patients with acute exacerbation of chronic obstructive pulmonary disease: a meta-analysis and systematic review
Abstract
This meta-analysis aimed to identify risk factors for ventilator-associated pneumonia (VAP) in patients with Acute exacerbations of Chronic obstructive pulmonary disease (AECOPD). We systematically searched PubMed, Web of Science, CINAHL, Cochrane Library, Embase, CNKI, and other databases for studies investigating risk factors for VAP in patients experiencing AECOPD. The search encompassed records from database inception up to July 2, 2025. The quality of the studies was assessed using the Newcastle-Ottawa Scale. Meta-analysis was performed using Stata 18.0. A total of 16 articles were included, encompassing 3,664 subjects and 16 risk factors. Meta-analysis results showed that, Age (OR: 2.49, 95%CI : 1.49, 4.17; P < 0.001), Smoking history (OR: 2.70, 95%CI : 1.65, 4.44; P < 0.001), Acute physiology and chronic health evaluation composite score (APACHE Ⅱ) score (OR: 3.03, 95%CI : 1.98, 4.65; P < 0.001), Sequential organ failure assessment (SOFA) score (OR: 2.75, 95%CI : 1.90, 3.99; P < 0.001), Diabetes (OR: 2.11, 95%CI : 1.38, 3.24; P = 0.001), Underlying Diseases (OR: 3.42, 95%CI : 1.85, 6.32; P < 0.001), Duration of mechanical ventilation (OR: 4.53, 95%CI : 2.68, 7.65; P < 0.001), Tracheal intubation (OR: 4.21, 95%CI : 1.85, 9.57; P = 0.001), Indwelling gastric tube (OR: 3.31, 95%CI : 1.38, 7.95; P = 0.008), Total parenteral nutrition (OR: 1.86, 95%CI : 1.29, 2.70; P = 0.001), Combined antibiotics (OR: 2.79, 95%CI : 1.32, 5.93; P = 0.007), Tracheotomy (OR: 2.92, 95%CI :…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 3,664 participants or records.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.