Impact of Oral Hygiene Protocols for Critically Ill Patients on Pseudomonas aeruginosa, a Major Pathogen of Ventilator-Associated Pneumonia: A Randomized Controlled Trial
Abstract
BACKGROUND: The oral hygiene of intensive care unit (ICU) patients influences the occurrence of nosocomial ventilator-associated pneumonia (VAP). Ventilator-associated pneumonia (VAP) is a common and serious clinical problem among critically ill patients with cardiovascular disease in the ICU. However, there is currently no definitive agreement on the most effective oral hygiene protocol.
AIM: To study the effects of different oral hygiene protocols in critically ill patients on the pathogens causing nosocomial pneumonia in the oral cavity.
METHODS: This study examined the microbiology of oral biotopes in patients treated in the intensive care unit (ICU) during a traditional oral hygiene protocol and a new oral hygiene protocol using an antiseptic based on an aqueous solution of electrochemically activated oxidants.
RESULTS: Based on the results of statistical analysis of comparison of two groups by microbial markers of nosocomial pneumonia before the study, it can be concluded that in the period "After treatment, day 1" there were significant differences in the decrease of the causative agent of nosocomial pneumonia "Pseudomonas aeruginosa" in group 2 (new protocol) to 0.00 (0.00; 3.00) compared to group 1 (traditional protocol) - 3.00 (0.50; 16.50), (P = 0.0022). In the period "Before treatment, day 2" there were significant differences in the decrease of "Pseudomonas aeruginosa" in group 2 (new protocol) to 1.50 (0.00; 17.00) compared to group 1 (traditional protocol)…
How strong is the evidence?
Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design.
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