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Effect of an oral care bundle on salivary pH, dry mouth and ventilator-associated pneumonia in intubated patients: a randomized controlled trial

G. Aktan, İsmet Eşer, M. Uyar

BMC Oral Health, 2026

35 participants

Abstract

More serious and costly problems can be prevented with systematic and holistic oral care, which seems to be less important among nursing practices. To determine the effectiveness of oral care bundle on oral health, saliva volume, saliva pH and VAP in intubated patients. This randomized controlled trial data was collected between January and December 2021 in the Anesthesiology and Reanimation ICUs at a university hospital. Patients were randomly assigned to intervention and control groups. While routine oral care was applied to the control group (abeslang wrapped in gauze), the intervention group was given care with the oral care bundle created by the researchers (brushing teeth, applying ice water, moisturizing). The primary outcome was the oral health score (BOE), and the primary endpoint was defined as the BOE score at Day 5. Secondary outcomes included saliva volume, salivary pH, ventilator-associated pneumonia. Repeated measures were analyzed using two-way repeated measures ANOVA for normally distributed variables and the Brunner–Langer model for non-normally distributed data. A total of 35 patients were analyzed (intervention: n = 17; control: n = 18). A significant group × time interaction was observed for the BOE score (p < 0.001), indicating an improvement in oral health over time in the intervention group compared with the control group. Similarly, a significant group × time interaction was found for saliva volume (p < 0.001). For salivary pH, a statistically…

How strong is the evidence?

Evidence Hub reads this as a randomized trial, done in people. Its evidence level is 2 of 5 (High · randomized trial). Randomized trials of a reasonable size are the strongest single-study design. Reported size: 35 participants or records.

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