Pneumocystis jirovecii pneumonia in paediatric acute lymphoblastic leukaemia: A report from the multi‐international clinical trial AIEOP‐BFM ALL 2009
Abstract
Pneumocystis jirovecii can cause life‐threatening pneumonia (PjP), and patients with haematological malignancies are at high risk of this infection. Prophylactic measures have significantly decreased morbidity and mortality, but there is a paucity of contemporary data on the incidence and clinical course of PjP in well‐defined and homogenous patient populations, such as children suffering from acute lymphoblastic leukaemia (ALL). In the multi‐international trial AIEOP‐BFM ALL2009, PjP was diagnosed in six children (incidence 1/1000) and was associated with insufficient prophylaxis in five of them. Although none of the patients died of PjP, the long‐term impact of the infection is unclear.
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