Association of the glucose-to-lymphocyte ratio with stroke-associated pneumonia among acute ischaemic stroke patients with dysphagia: a secondary analysis of hospital-based observational data
Abstract
Stroke-associated pneumonia (SAP) is a frequent complication after acute ischaemic stroke, particularly in patients with dysphagia. The glucose-to-lymphocyte ratio (GLR) is a simple biomarker measured at admission reflecting stress hyperglycaemia and stroke-related immune suppression, but its value in dysphagic stroke populations remains uncertain. In this secondary analysis of hospital-based observational data, we investigated the association between admission GLR and SAP in 681 Vietnamese patients with acute ischaemic stroke and dysphagia treated at a tertiary referral hospital in Hanoi. SAP was defined as a lower respiratory tract infection occurring within 7 days after stroke onset according to the modified Pneumonia in stroke consensus group criteria. GLR was measured in the first admission blood sample and analysed per 1-standard-deviation increase and by quartiles. Logistic regression models were adjusted for demographic and clinical covariates. The incremental value of GLR was assessed by comparing a clinical model with and without GLR. SAP occurred in 70 of 681 patients (10.3%; 95% CI 8.2 to 12.8). Patients with SAP were older, more often had previous stroke, more severe stroke and dysphagia, lower lymphocyte counts, higher GLR values and higher in-hospital mortality. In crude analysis, each 1-standard-deviation increase in GLR was associated with higher odds of SAP (odds ratio [OR] 1.24, 95% confidence interval [CI] 1.001 to 1.53), an association of borderline…
How strong is the evidence?
Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 681 participants or records.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.