Fugitive medical and patient-derived aerosol particle distribution following heparin nebulization in patients with COVID-19 acute hypoxemic respiratory failure: a secondary analysis of the CHARTER study
Abstract
, Aerosolisation is an effective delivery mechanism for direct delivery of therapeutics into the lung and has the potential to reduce systemic side effects. However, the potential for and extent of environmental contamination associated with aerosolisation needs to be determined, particularly whether this is influenced by oxygen delivery devices. The aim of this study was to determine the distribution of fugitive medical and patient-derived aerosols around the bed spaces of patients undergoing the management of COVID-19 pneumonia and determine differences in the aerosol particle distribution based on device used for respiratory support. A convenience sample of patients from the ‘Can Nebulised HepArin Reduce acuTE lung injury in Patients with SARS-CoV-2 Requiring Mechanical Ventilation in Ireland (CHARTER-Ireland
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Evidence Hub reads this as a secondary / pooled analysis, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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