A55-25 Characterisation and Outcomes of ARDS Secondary to Pneumonia in Patients With COPD: A Single Centre Experience
Abstract
Acute respiratory distress syndrome (ARDS) is the major cause of mortality in patients with community-acquired pneumonia(CAP). However, it is not clear yet the incidence of ARDS in patients with COPD whom developed CAP.
Was to determine the risk factors for development ARDS secondary to CAP in COPD patients with differential inflammatory type of the disease.
It was restrospective study from university hospital and have been investigated by radiological,microbiological ,and biochemistry analysis. In all patients have been used conventional oxygen therapy (COT) with further using of CPAP and HFNO and mechanical ventilation (MV) if there were indications to that.
126 patients with COPD exacerbations whom developed CAP and in 39 patients of them(30.96) developed ARDS.The patients with COPD complicated with CAP and ARDS were older(p 200 and <300).The response to the HFNO was hgier in Th2-type inflammation COPD phenotype patients and it was result for just 3 intubated patients in this group compared to 20 intubated patients in non-Th2-type inflammation patients group(OR3.54[1.32-7.21];p<0.001).Risk factors for development of ARDS in patients were: septic shock at the time of admissionof patietns(p < 0.001);previous ICU admission (p < 0.001);high SOFA score (p < 0.002);and gram -negative multidrug bactera(MDRB) (OR 4.22[079-9.42];p<0.0004).Duration of mechanical ventilation was significantly lower in Th2-type inflammation COPD (2.48[1.02-5.28];p<0.004).30-day mortality rate was…
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