Development of a novel model for accurate prediction of secondary Candida pneumonia in patients with acute exacerbation of chronic obstructive pulmonary disease
Abstract
Background Given the increased risk factors such as the wide application of various dose forms of corticosteroids and broad-spectrum antibiotics in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) in recent years, the incidence of invasive Candida pneumonia secondary to AECOPD tends to increase. However, Candida infections secondary to AECOPD are often neglected in clinical practice, or even misdiagnosed as bacterial infections, resulting in disease deterioration due to delayed diagnosis. Knowing that early diagnosis and timely treatment can obviously improve the prognosis of pulmonary candidiasis, improving the early diagnosis rate is the key to reduce the mortality of AECOPD-associated candidiasis. The present study was intended to develop a new model that can early and accurately predict the occurrence of Candida infections secondary to AECOPD. Methods Clinical data of 164 hospitalized patients with AECOPD who received treatment in the department of respiratory medicine of Yiwu Central Hospital between January 2022 and January 2024 were reviewed retrospectively, including the diagnosis, gender, age, BMI, use of inhaled corticosteroids, the duration of using antibiotics, use of carbapenem antibiotics, random blood glucose, albumin level, the presence or absence of cerebral infarction aspiration, cancer chemoradiotherapy, complicated cardiovascular disease, procalcitonin level, pulmonary function grade, and surviving time. Data were treated…
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.