P-2280. Community-Acquired Pneumonia in Immunosuppressed Patients Admitted to the ICU
Abstract
Abstract Background Severe community-acquired pneumonia (sCAP) remains a crucial infectious cause of global mortality, accounting for a significant proportion of ICU admissions. Immunosuppressed patients frequently develop sCAP; however, the clinical characteristics and clinical outcomes of patients admitted to the ICU due to sCAP are not clear. Here, we attempted to bridge this gap in the literature. Figure 1 Isolated microorganisms in respiratory samples. A. General cohort; B. No immunosuppression risk factors group; C. Immunosuppression risk factors group Methods This secondary analysis of the prospective MIMIC-IV database included adults admitted to the ICU with CAP diagnosis. Patients were stratified based on the presence or absence of immunosuppression. Bivariate, multivariate, and survival analyses were conducted to identify factors associated with mortality within the immunosuppressed and their impact on hospital mortality. Figure 2 Kaplan-Meier survival curve of 1-year after discharge survival probability stratified by immunosuppression status. Patients with and without immunosuppression are represented, the first group with 1 (blue) and the last with 0 (red). Results A total of 4742 patients were included, with 1502/4742 (32%) being immunocompromised. The mean age (SD) was 66 ±16.1years, with 2627/4742 (55.4%) males. A total of 1384 respiratory isolations were obtained with Staphylococcus aureus (43.2% vs. 40.6%; p= 0.45) and Pseudomonas aeruginosa (10.20 % vs…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 4,742 participants or records.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.