Endoscopic-guided cultures in pediatric recurrent acute rhinosinusitis
Abstract
BACKGROUND: Rhinosinusitis is a highly prevalent disease among children. Many pathogens cause acute bacterial rhinosinusitis; however, literature is scarce when it comes to identifying bacteria responsible for pediatric recurrent acute rhinosinusitis (PRARS). This study aims to identify the most common organisms causing PRARS along with antimicrobial susceptibility, ideally with an endoscopic-guided culture from the middle meatus.
METHODS: Retrospective data were collected between 2017 and 2023 for all PRARS patients who attended a pediatric ENT clinic at a tertiary hospital. Demographic characteristics and clinical data of 109 children were gathered. Samples were obtained through endoscopic-guided middle meatal cultures under general anesthesia.
RESULTS: Cultures were positive in 56 patients (51.4 %) consisting of either one or more organisms. The incidence of positive bacterial cultures was higher in the post-Covid19 era (74 versus 35). The predominant solo organism isolated was Moraxella species, accounting for 31.8 % of the total positive cultures. The second most common organism was Haemophilus influenzae (21.2 %). Staphylococcus aureus (18.2 %) was the third most isolated organism. Almost all Moraxella isolates were sensitive to amoxicillin-clavulanic acid, macrolides, and cefuroxime (100 %, 100 %, and 95 %, respectively). All Haemophilus isolates were 100 % sensitive to ceftriaxone and levofloxacin. All Streptococcus pneumoniae isolates were 100 % sensitive to…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 109 participants or records.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Ferulic acid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure–Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Photochemical behavior of levofloxacin
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.