Trends of antimicrobial resistance in bloodstream infections at a large traditional Chinese medicine hospital in China: a 10-year surveillance study (2015-2024)
Abstract
BACKGROUND: This study aimed to explore the distribution and antimicrobial resistance of bloodstream infections (BSIs) pathogens at a large traditional Chinese medicine hospital in China.
METHODS: Retrospective analysis of the pathogen distribution of BSIs and the changes in antimicrobial resistance during a 10-year period (2015-2024) was conducted in Longhua Hospital. Isolate identification was carried out by VITEK®2 Compact. Antimicrobial susceptibility testing was performed by minimum inhibitory concentration (MIC) determination.
RESULTS: The most common Gram-negative and Gram-positive BSI-causing bacteria were Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), respectively. The isolation rate of E. coli dropped sharply from 37.33% in 2015-2016 to 15.37% in 2023-2024 (P < 0.01). E. coli displayed the highest sensitivity rates to imipenem, meropenem, and amikacin, with sensitivity rates exceeding 90.00%. The dramatic decreasing trends were observed for Klebsiella pneumoniae (K. pneumoniae) resistance to piperacillin/tazobactam (TZP), cephalosporins, imipenem, meropenem, tobramycin, and levofloxacin. S. aureus had a relatively high resistance rate to penicillin G, and the resistance rate of S. aureus to levofloxacin and moxifloxacin appeared to be rising. The isolation rate of methicillin-resistant S. aureus (MRSA) ranged from 25.00% to 40.00%. Kaplan-Meier survival analysis showed that Acinetobacter baumannii (A. baumannii) infection was associated with a…
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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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