Bacterial bloodstream infections in a pediatric population: A 7-year experience at a tertiary care center in Saudi Arabia
Abstract
OBJECTIVES: This study explored the epidemiological trends and antimicrobial susceptibility patterns of bloodstream pathogens among pediatric patients over a 7-year period at a tertiary care facility in Saudi Arabia.
METHODS: This retrospective single-center longitudinal descriptive study was conducted from 2015 to 2021. Blood culture and susceptibility data of pathogens isolated from patients aged <15 years were extracted from the hospital's laboratory information system. The trends observed over the 7-year period were graphically illustrated.
RESULTS: Among the 83,605 pediatric blood cultures analyzed, 2945 (3.5 %) tested positive. Approximately 65 % of the positive cultures were confirmed as true bloodstream infections (BSIs), with an average BSI rate of 3 per 1000 inpatient days. Gram-negative bacterial infections accounted for 61 % of BSIs, with Klebsiella spp. being the most prevalent. Susceptibility testing revealed reduced sensitivity to meropenem, imipenem, ciprofloxacin, and levofloxacin among gram-negative bacteria. Gram-positive pathogens represented 39 % of infections, with the most common being Staphylococcus spp. (21 %) and Streptococcus spp. (7 %). Methicillin-resistant Staphylococcus aureus exhibited 100 % sensitivity to vancomycin, quinupristin/dalfopristin, tigecycline, and linezolid. However, Streptococcus pneumoniae showed decreasing sensitivity to penicillin and ceftriaxone for meningitis (33 % and 55 % susceptibility, respectively). Furthermore,…
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Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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