P-2243. Multiplex PCR Pneumonia Panel in Critically Ill Patients Did Not Modify Mortality. A Cohort Study
Abstract
Abstract Background Severe pneumonia is a common cause of Intensive Care Unit (ICU) admissions. In critically ill patients, identification of the pathogen may allow timely adjustment of antibiotics and, therefore improve outcomes. The aim of this study was to assess whether performing a multiplex polymerase chain reaction (PCR) pneumonia panel in patients with pneumonia in ICU, has any effect on mortality, overall stay, ICU stay and duration of antimicrobial therapy. Methods A retrospective cohort study was conducted on adult patients with pneumonia who required ICU admission at 4 hospitals in Bogota Colombia, between November 2019 and June 2023. Patients who underwent multiplex PCR pneumonia panel testing were defined as exposed. Mortality at 30 days, length of hospital and ICU stay, duration of antibiotics and, their association with multiplex PCR pneumonia panel testing were evaluated using and Inverse Probability of Treatment Weighting (IPTW) to adjust for covariates and potential confounders. The infectious diseases specialist’s assessment and its effect on antibiotics adjustment was also determined. Mortality analysis Results 304 patients were included, 150 exposed, 154 non-exposed. Mean age 65.0 years (SD 14.6) and mean Charlson index 4.5 (SD 2.8). 186 (61.2%) patients had COVID-19 and 256 (84.2%) community acquired pneumonia. Length of hospital stay was 20.8 days (SD 17.0), ICU stay was 12.2 days (SD 10.9), total number of antibiotics administered was 2.7 (SD 1.7).…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 304 participants or records.
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