High‐dose vitamin D supplementation in patients with severe acute respiratory syndrome coronavirus 2 pneumonia hospitalized in a polyvalent intensive care unit: A retrospective cohort study
Abstract
The health benefits of vitamin D are far beyond bone mineral metabolism. Vitamin D has immunomodulator and anti‐inflammatory properties and its role in critically ill patients is controversial. The purpose of the study is to understand whether high doses of vitamin D supplementation are beneficial in patients with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pneumonia hospitalized in a polyvalent intensive care unit (ICU) and correlate to all‐cause mortality, need for invasive mechanical ventilation, and duration of hospitalization.
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence.
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