Nonlinear association between admission oxygen partial pressure and in-hospital and one-year all-cause mortality in patients with coronavirus disease pneumonia: A retrospective cohort study
Abstract
Background: This study investigated the correlation between admission partial pressure of arterial oxygen (PaO2) levels and both in-hospital mortality and 1-year all-cause mortality among patients diagnosed with coronavirus disease (COVID-19) pneumonia. Methods: This retrospective cohort study included patients with COVID-19 pneumonia admitted to the First Hospital of Jinzhou Medical University. Restricted cubic spline regression and logistic regression analyses were employed to assess the relation between PaO2 levels and the risk of in-hospital mortality and all-cause mortality within 1 year. Subgroup analyses were performed, stratified by age, sex, presence of cardiac disease, diabetes, hypertension, whether supplemental oxygen was provided during arterial blood gas analysis, and severity of pneumonia. Results: The study included 737 participants with in-hospital and 1-year all-cause mortality rates of 15.7% and 26.7%, respectively. Restricted cubic spline analysis revealed an L-shaped association between admission PaO2 levels and in-hospital mortality (P nonlinear <0.001) and a U-shaped relation with 1-year all-cause mortality (P nonlinear <0.001), with a nadir risk of 82 mmHg. Threshold analyses indicated an odds ratio of 0.931 (95% confidence interval (CI): 0.91–0.952) for in-hospital mortality and 0.951 (95% CI: 0.933–0.969) for 1-year all-cause mortality when PaO2 was <82 mmHg. Conversely, when PaO2 was ≥82 mmHg, the odds ratio for in-hospital mortality was 1.022 (95%…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 737 participants or records.
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