Delay and factors associated with early clinical stability during community-acquired pneumonia: a case control study
Abstract
In this case-control study of 231 hospitalized patients with community-acquired pneumonia (CAP), 61% achieved clinical stability by Day 3. Residence in a long-term care facility (adjusted OR 4.1, 95% CI 1.6-11.4) and active neoplasia (adjusted OR 5.5, 95% CI 1.5-25.9) were independently associated with failure to reach early stability. Persistent oxygen requirement was the leading criterion for instability. Early stability correlated with lower mortality (2.1% vs 17.8%) and fewer ICU admissions (0% vs 12.2%). These findings underscore the prognostic value of stability assessment and support individualized antibiotic duration based on patient characteristics.
How strong is the evidence?
Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 231 participants or records.
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