Incidence and risk profiles for pneumonia in patients with schizophrenia receiving home-care case management intervention in Taiwan
Abstract
Background: Home-care case management is a type of community outreach service. However, research on the incidence of infectious diseases in patients receiving home-care case management is limited. This study investigated the incidence of various infectious diseases and risk factors for pneumonia in patients with schizophrenia receiving home-care case management. Methods: We used data from Taiwan’s National Health Insurance Research Database between January 1, 2000, and December 31, 2019, to construct a schizophrenia cohort receiving home-care case management (n = 19,687). Pneumonia was the most common infectious disease at follow-up (n = 3966). To identify risk factors for pneumonia, a nested case–control study was conducted. Risk-set sampling was conducted to randomly select controls for each pneumonia case. Conditional logistic regression was employed for statistical analysis. Results: Among various infectious diseases, pneumonia had the highest standardized incidence ratio in our cohort. Of the 3966 patients with pneumonia identified, 56.9% were men. After pairing, 3961 case–control pairs were established. Psychiatric comorbidities, specifically dementia and depressive disorders, were associated with a higher risk of pneumonia (adjusted incidence rate ratios [aIRRs] = 2.73 and 1.34, respectively). In contrast to oral antipsychotics, long-acting injectables were not associated with an increased pneumonia risk, suggesting that long-acting injectables could be a safer…
How strong is the evidence?
Evidence Hub reads this as a cohort study, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 19,687 participants or records.
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