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Risk factors analysis of poor prognosis in ICU-admitted children with severe influenza pneumonia: a retrospective case-control study

Zhaoqian Shan, Wan-Yu Jia, Wanying Li, Peng Li, Chun-lan Song

Italian Journal of Pediatrics, 2026

139 participants

Abstract

This study investigated independent prognostic risk factors for adverse outcomes in children admitted to the ICU with severe influenza pneumonia to guide early risk stratification and timely clinical intervention. This retrospective study included 139 eligible pediatric ICU patients with severe influenza pneumonia. Univariate and multivariate logistic regression was applied to analyze the independent risk factors for poor prognosis with severe influenza pneumonia, and the Receiver operating characteristic (ROC) curve was used to evaluate the effectiveness of risk factors. Among the 139 children, 45 had a poor prognosis and 94 had a good prognosis. Multiple clinical and laboratory parameters differed significantly between the two groups (all P\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\:<$$\end{document}0.05). The three independent risk factors associated with poor prognosis were identified: fever peek \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\:\ge\:\:$$\end{document}41\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy}…

How strong is the evidence?

Evidence Hub reads this as a case-control, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 139 participants or records.

How the five levels of evidence work. The level is assigned automatically from the abstract and can be wrong, so check the paper.

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