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The lung microbiome in patients with HIV complicated with community-acquired pneumonia: a cross-sectional pilot study

Yang Song, Xin-Min Xu, Meng-Jiao Xie, Jing Tao, Huiling Jin, Yang Liu, Li Liu, Xiao-Hui Song et al.

Current Research in Microbial Sciences, 2025

Abstract

Highlights • The lung microbiome of patients with HIV-CAP is dominated by Gammaproteobacteria.• AIDS group showed higher pathogenic taxa and lower symbiotic bacteria.• AIDS patients had destabilized microbial networks.• Immune collapse shifted microbiome from cooperative hubs to competitive modules.

How strong is the evidence?

Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.

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