Hyponatremic Events Occurring in Hypertensive Patients While Taking Thiazide Diuretic: Cross-Sectional Study
Abstract
Background: Hyponatremia is common with thiazide. We evaluated how commonly hyponatremia occurs among Nepalese hypertensive patients while they are kept on thiazide.
Method: It was a cross-sectional study, conducted from 2017-March to 2018-March at Bir hospital and Annapurna Neurological Institute & Allied Sciences, Kathmandu. Data on demography, Thiazide diuretics, use of other medicines and laboratory investigation were obtained from all the hypertensive patients. Four hundred twenty-three patients who met the inclusion criteria i.e., Adult hypertensive patients while on Thiazide diuretic with or without Ca+ Channel blocker (CCB), with or without Angiotensin Receptor Blocker/Angiotensinogen converting enzyme inhibitor (ARB/ACEI) and taking diet orally were enrolled in this study. Conditions like SIADH (syndrome of Inappropriate Anti Diuretic Hormone), congestive heart failure, liver failure, renal failure, or pneumonia and drugs likely to cause hyponatremia were excluded. Serum osmolality was calculated and patients having normal osmolality i.e., 280-300 mos/l was included. Hyponatremia was categorized based on serum level of sodium as Mild (120-134 mmol/l), Moderate (110- 119mmol/l), and Severe (<110mmol/l and/or Symptoms like seizure, disorientation, lethargy, loss of consciousness). Chi-squared tests were used for comparisons between categorical data and multiple regression analysis was used to measure interrelationships between variables in the study population.…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 423 participants or records.
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