Prevalence of Drug-Resistant Klebsiella pneumoniae Strains in Hospitalized Patients in Mashhad, Iran: A Cross-Sectional Study
Abstract
Background: Klebsiella pneumoniae is one of the important bacilli of the Enterobacteriaceae family and is considered as the primary pathogen in nosocomial infections, especially septicemia, pneumonia, etc. Widespread resistance to antibiotics is currently a major concern worldwide. The aim of this study is to determine the prevalence of antibiotic resistance and its association with variables such as age, gender, and department.
Methods: 90 strains of Klebsiella pneumoniae were identified by the phenotypic method and BD Phoenix M50, and the Phoenix system determined their antibiotic resistance according to the manufacturer's procedures. Then, a statistical relationship between antibiotic resistance and variables, including age, gender, and patient department, was obtained.
Results: The findings indicated that the Multidrug-resistant (MDR) and Extended-Spectrum Beta- Lactamase (ESBL) resistance in patients had a high prevalence (above 80%). The intensive care units (ICUs) and burn wards had the highest prevalence of these antibiotic resistance. Comparing drug resistance with gender showed that total drug resistance (TDR) was significantly higher in men. However, no statistically significant relationship was found between them and age.
Conclusion: Based on the findings, the high prevalence of antibiotic resistance in Klebsiella pneumoniae requires special attention to their control and prevention, especially in critical departments such as ICU and burn units, and therapeutic…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause.
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