Association between ABO Blood Group and COVID-19 Pneumonia Severity: A Cross-Sectional Study from Ethiopia's First Designated COVID-19 Treatment Center
Abstract
ABSTRACT Background: Coronavirus disease 2019 (COVID19), caused by severe acute respiratory syndrome coronavirus 2, spreads rapidly and can cause severe acute respiratory failure; advanced age, chronic disease, and other comorbidities increase the risk of severe infection. By early 2022, more than 477 million cases and 6.11 million deaths had been reported globally. This study assessed the association between ABO blood group and severity of COVID-19 pneumonia among patients admitted to Eka Kotebe General Hospital, Addis Ababa, Ethiopia. Methods: A hospital-based cross-sectional study was conducted using systematic random sampling; data were abstracted from patient records, and severity was modeled using ordinal logistic regression, with multicollinearity and the proportional odds assumption checked via the variance inflation factor and test of parallel lines, and model fit assessed by likelihood ratio chi-square and goodness of fit tests. Results: Of 355 patients included (100% response rate), 54.9% were male and 31.0% were older than 61 years (median age, 48 years; interquartile range, 33-65). Overall, 10.14% were asymptomatic, 24.79% had mild/moderate disease, 60.56% had severe disease, and 4.51% had critical disease. Pregnancy and presence of complications were significantly associated with severity (adjusted odds ratio, 0.15 [95% CI, 0.04-0.57] and 14.96 [95% CI, 4.14-54.01], respectively); ABO blood group showed no association with severity. Conclusion: These findings…
How strong is the evidence?
Evidence Hub reads this as a cross-sectional, done in people. Its evidence level is 4 of 5 (Low · observational). Observational designs can show an association but not prove cause. Reported size: 355 participants or records.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.