Extracorporeal membrane oxygenation support for four patients with acquired immunodeficiency syndrome complicated by pneumocystis pneumonia: a case series and literature review
Abstract
Background Acquired immunodeficiency syndrome (AIDS) complicated by Pneumocystis pneumonia (PCP) is characterized by an insidious onset, rapid progression, and a critical clinical course. Severe complications, such as respiratory failure and pneumothorax, may occur in the absence of timely and effective intervention, resulting in increased mortality. Extracorporeal membrane oxygenation (ECMO) can serve as a salvage therapy by temporarily and effectively replacing cardiopulmonary function. Objective We aimed to summarize the clinical experience of veno-venous extracorporeal membrane oxygenation (V-V ECMO) support in four patients with AIDS complicated by PCP. Methods Clinical data from four patients with AIDS who were complicated by PCP and received ECMO support at Beijing Ditan Hospital, Capital Medical University, were retrospectively analyzed. The timing of ECMO initiation, mode selection, mechanical ventilation (MV) management, sedation and analgesia strategies, prognosis, and clinical experience were evaluated, and treatment experience was summarized. Results All four patients were definitively diagnosed with AIDS complicated by PCP and respiratory failure. All patients received ventilatory support and developed barotrauma. Pneumothorax occurred in cases 1, 2, and 4, whereas pneumomediastinum was detected in case 3. All patients received V-V ECMO support, which improved clinical conditions in all cases. Finally, cases 1 and 2 died, whereas cases 3 and 4 recovered and…
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.