846. Venovenous ECMO for Burn Patients with Acute Hypoxemic Respiratory Failure: Single Center Case Series
Abstract
Abstract Introduction Hypoxemic respiratory failure is a common cause of mortality in burn patients. Complications of burns including inhalation injury, pulmonary edema, sepsis, and pneumonia increase patients’ risk of developing acute respiratory distress syndrome (ARDS). Current ARDS management includes lung-protective mechanical ventilation, prone positioning, promoting negative fluid balance, and glucocorticoids. Adjuncts of inhaled vasodilators and neuromuscular blockade show less-defined mortality benefit. In cases of severe ARDS with refractory hypoxemia, venovenous extracorporeal membrane oxygenation (VV-ECMO) can provide pulmonary support as the patient’s disease course resolves. Data on ECMO’s benefit in this patient population remain limited. Methods This IRB-approved retrospective case series identified adult patients from our ABA-verified burn center who underwent VV-ECMO at our ECMO-capable sister tertiary care hospital between July 2020 and December 2024. We included patients with acute burn or inhalation injuries who developed severe ARDS or life-threatening hypoxemia refractory to conventional therapy. Results We identified 10 patients who underwent VV-ECMO with a mean age of 46.1 ± 15.0 (mean ± standard deviation) years. Six patients had flame burns, 3 had isolated inhalation injury, and 1 had an electrical injury. The 7 patients with cutaneous burns had a mean total burn surface area of 16.0 ± 13.0%, ranging from 0.3% to 35%. The mean PaO2/FiO2 ratio…
How strong is the evidence?
Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health. Reported size: 10 participants or records.
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.