Melioidosis in Sickle Cell Hemoglobinopathies in Eastern India: Cavitating Pneumonia and Immune Susceptibility - A Case Series-Based Insight
Abstract
Melioidosis, caused by Burkholderia pseudomallei, is an emerging infection in the tropics. Most of the melioidosis patients have underlying co-morbidities or occupational exposures. Hemoglobinopathies, such as thalassemia, are established risk factors for melioidosis; however, the association of SCD with melioidosis is infrequently reported. We report two culture-confirmed melioidosis cases from eastern India: a 58-year-old male with SCD on hydroxyurea and another 44-year-old with sickle cell trait, both presenting with cavitary lung lesions mimicking tuberculosis. SCD-related functional asplenia may heighten susceptibility. These cases emphasise the need for clinical vigilance in endemic areas and further research into SCD/SCT-associated immune vulnerabilities.
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Evidence Hub reads this as a case series, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.
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