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Levofloxacin-induced Hypoglycemia in elderly: A Rare but Life-threatening Side Effect of a Widely Used Antibiotic - A Case Report

Mahendra Agrahari, Ranjita Singh, K. Sapkota

Journal of Advances in Internal Medicine, 2025

Abstract

Levofloxacin is one of the most commonly prescribed antimicrobial agents. However, hypoglycemia due to levofloxacin in elderly is a rarely reported complication and, to our knowledge, only few cases have been published. As it is given in intravenous form in various doses and now days the drug doses been increased so one should be careful using this drug. Elderly patients have associated disease like diabetes, kidney disease and liver disease which may prone to accelerate its effect. We report this rare case of an uncommon but potentially fatal side effect of levofloxacin. This report highlights the importance of recognizing levofloxacin as a potential trigger for hypoglycemia, especially in individuals with preexisting diabetes.

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Evidence Hub reads this as a case report, done in people. Its evidence level is 5 of 5 (Very low · case / narrative / animal / in vitro / in silico). Case reports, narrative reviews, and animal, cell or computer-model studies give the weakest evidence for human health.

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