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A Perfect Storm: Pulmonary Edema Following Misoprostol Administration in the Midst of Sepsis, Pneumonia, and Retained Pregnancy: A Rare Case Report

Rahul Kumar Chaudhary, L. Rajbanshi, Deepak Poudel, Kumud Pyakurel, P. Bista

Clinical Case Reports, 2025

Abstract

Pulmonary edema is a rare but serious event that can occur in critically ill obstetric patients with multiple comorbidities. This case describes its occurrence following misoprostol administration in a highly vulnerable patient with sepsis, preeclampsia, and intrauterine fetal demise. While a temporal association was observed, causation cannot be definitively established. This report highlights the importance of vigilant monitoring and readiness for advanced respiratory support when using uterotonics in high‐risk, destabilized patients. It is crucial to emphasize that misoprostol remains a safe and lifesaving medication for the vast majority of obstetric patients, and this unique case should not deter its essential use.

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