P-1504. Propensity-Matched Comparison of Early vs. Late Antibiotic Therapy in Stenotrophomonas maltophilia Pneumonia: A Five-Hospital Study
Abstract
Abstract Background Stenotrophomonas maltophilia is a leading drug-resistant nosocomial pathogen worldwide. First-line antibiotic therapy for S. maltophilia is not a routine part of empiric antibiotic coverage. This study aimed to evaluate clinical outcomes of patients receiving early versus late antibiotic therapy for S. maltophilia pneumonia (PNA).Table 1. Baseline and Clinical Course Characteristics aData are presented as “number (%)” or “median (interquartile range)”, as appropriate. Abbreviations: BMI, body mass index; CrCL, creatinine clearance; LTAC, long-term acute care; NH/LTC, nursing home/long-term care. Methods A retrospective, observational study was conducted at five hospitals within University of Kentucky HealthCare. Patients treated for S. maltophilia PNA between 1/1/2014 and 12/31/2023 receiving sulfamethoxazole/trimethoprim, minocycline or levofloxacin with reported in-vitro susceptibility were included. Patient and bacterial characteristics, all-cause mortality, and desirability of outcome ranking (DOOR) at 30 days were compared between patients receiving early (≤48 hours of culture collection) versus late ( >48 hours of culture collection) therapy (Table 1). Propensity-score matching (PSM) was used to adjust confounding. Subgroup and sensitivity analyses were used to verify the robustness of results.Table 2. Desirability of Outcome Ranking (DOOR) Results Median age of patients was 64 years (interquartile range [IQR] 52-71 years). The median Charlson…
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.