Emergence of ST11-KL64 carbapenem-resistant hypervirulent Klebsiella Pneumoniae isolates harboring blaKPC−2 and iucA from a tertiary teaching hospital in Western China
Abstract
Abstract Background Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP) poses a critical global health threat. However, molecular epidemiological data on CR-HvKP in Western China remain scarce. This study aimed to characterize the clinical profiles, molecular features, and risk factors of CR-HvKP isolates in Western China. Methods Sixty-eight carbapenem-resistant Klebsiella pneumoniae (CRKP) clinical isolates were collected from January to December in 2024. Clinical characterization included antimicrobial susceptibility profiling and hypermucoviscosity assessment via string test. Detection of carbapenemases using inhibitor enhancement test. Molecular characteristics of CRKP included serotype, carbapenemases, virulence-associated factors, and multilocus sequence typing (MLST) performed by using the PCR method. CR-HvKP was defined as the presence of any one of rmpA , rmpA2 , iroB , iucA , and peg-344 . Risk factors were initially evaluated using univariate logistic regression analysis, with significant variables subsequently incorporated into a multivariate regression model. A p -value < 0.05 was considered statistically significant. Results Among 68 CRKP isolates, 36 were identified as CR-HvKP, all harboring the iucA gene (100%, 36/36). However, only 22.2% (8/36) of string test results correlated with virulence gene presence. All CRKP strains exhibited high resistance to most antibiotics, with comparatively lower resistance rates observed for tigecycline (0%)…
Read the paper
Related studies
- Severe clinical outcomes of COVID-19 associated with proton pump inhibitors: a nationwide cohort study with propensity score matching
- Levofloxacin-Induced Tendon Rupture: A Case Report and Review of the Literature
- Association between cord blood 25-hydroxyvitamin D concentrations and respiratory tract infections in the first 6 months of age in a Korean population: a birth cohort study (COCOA)
- Neuroprotective Effects of Epicatechin against Oxidative Stress-Induced Cognitive Impairment: A Systematic Review and Meta-Analysis
- Quality evaluation and in vitro interaction studies between levofloxacin 250mg and diclofenac sodium 50mg tablets
- Molecular Epidemiology of mcr-1 -Positive Polymyxin B-Resistant Escherichia coli Producing Extended-Spectrum β-Lactamase (ESBL) in a Tertiary Hospital in Shandong, China
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.