Comparing calculated and experimental activity and dose values obtained from image-based quantification of 90Y SPECT/CT Data
Abstract
PURPOSE
Selective internal radiation therapy (SIRT) is a treatment for various kinds of liver tumours by injecting 90Y bearing microspheres into the liver vessels. To perform meaningful post-treatment dosimetry, quantitative imaging is performed.
METHODS
This work uses a Monte-Carlo based reconstruction software with scatter and attenuation correction and collimator modelling that allows the quantification of 90Y bremsstrahlung SPECT/CT data. A dataset comprising 17 patients and measurements on a Jaszczak phantom, a NEMA IEC Body phantom and an anthropomorphic liver phantom are analysed and activities and dose values are acquired. These measured values are compared with applied activities and pre-treatment calculations, allowing to assess the quality of the SPECT reconstruction. A detailed uncertainty budget is presented, including uncertainties of the dose calibrator, the count rate, non-included interactions and other factors.
RESULTS
The applied method is validated by finding measurements repeatable within the given uncertainty, and it is shown the influence of various parameters on the reconstruction process is negligible. Furthermore, activities and doses measured in the phantoms show good agreement with calculated values, if they are corrected for partial volume effects.
CONCLUSIONS
The strict observation of metrological requirements and the creation of an uncertainty budget increase the reliability and traceability of this novel approach to 90Y dosimetry. It gives an…
Read the paper
Related studies
- Quantitative accuracy of 177Lu SPECT reconstruction using different compensation methods: phantom and patient studies
- Technique alternatives for breast radiation oncology: Conventional radiation therapy to tomotherapy
- Acceptance procedure for the linear accelerator component of the 1.5 T MRI‐linac
- Preclinical Single Photon Emission Computed Tomography of Alpha Particle-Emitting Radium-223
- Preclinical Modeling of Image-Guided Craniospinal Irradiation for Very-High-Risk Medulloblastoma
- Hand-held dental X-ray device: Attention to correct use
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.