High-Energy Imaging Capability of a State-of-the-Art Full-Ring CZT SPECT/CT
Abstract
A full-ring CZT-based single photon emission computed tomography (SPECT) is the current state-of-the-art for SPECT imaging. This modern clinical SPECT (e.g., StarGuide, GE HealthCare) is offered as SPECT/CT with 12 small rectangular CZT detector modules, allowing multiple degrees of freedom to focus and contour the imaging object. While this advance is a significant improvement from conventional NaI-based systems, there is a fundamental challenge to completely take over all applications of SPECT, i.e., lack of high energy photon imaging capability required for imaging radionuclides with high-energy photon emissions (e.g., ${ }^{131} \mathrm{I}$ and ${ }^{225} \text{Ac}$). This deficiency comes from the fact that it is not easily feasible to change collimators between scans. As a close academic-industry collaborative research effort, we have evaluated strategies to overcome this challenge by redesigning collimator geometries using validated Monte Carlo simulation tools and advanced image reconstructions. The validation step for the Monte Carlo simulation was performed using experimental data. First, we performed a NEMA body phantom scans with ${ }^{177} \text{Lu}$, and confirmed the imaging performance for both the low (113 keV) and high energy (208 keV) peaks of ${ }^{177} \text{Lu}$ by both simulation and experimental data. Then, we tested if the current configuration of the collimator and detector shielding was able to image ${ }^{131} \mathrm{I}$ (364 keV) and ${ }^{213}…
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