Multi-Isotope Pre-Clinical Imaging Studies with DE-SPECT: A Hyperspectral Spect System for Region-Selective 3-D Gamma-Ray Spectrometry of Cardiovascular Disease
Abstract
We present the DE-SPECT system, a region-selective clinical SPECT system designed for highperformance cardiovascular imaging. The system features six stationary CZT detector panels with dual-FOV collimators that enable rapid switching between a 28 cm wide field-of-view (FOV) and a 16 cm high-resolution, high-sensitivity (HR-HS) FOV. We evaluated DE-SPECT in large animal models of acute and chronic cardiovascular injury. Multi-isotope imaging with Tc-99m-tetrofosmin, I-123-MIBG, Ga-67 Citrate was used to visualize perfusion, sympathetic innervation and inflammation. A joint reconstruction algorithm was applied to combine a wide FOV with high resolution in the targeted region. We further demonstrated 1 -second dynamic imaging of tracer kinetics enabled by the system's high sensitivity and stationary geometry. These results establish the DE-SPECT as a versatile platform for dynamic, high-resolution, and multi-tracer imaging in cardiovascular disease.
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