Investigation of Brain Mechanisms Involved in the Urinary Continence Mechanism Associated With Aging
Abstract
Urge urinary incontinence (UUI) is a common problem in older people which vastly reduces quality of life, yet the cause and mechanism of disease are not well understood. This study will characterize brain control of the bladder in young and old continent individuals and age-matched incontinent counterparts. This will expand the investigators current knowledge of how the brain controls the bladder, how that control changes with age and disease, and suggest new targets to guide development of better treatment.
Conditions: Urgency Urinary Incontinence.
Primary outcome: BOLD (Blood oxygen level dependent) fMRI signal contrast - mPFC; BOLD (Blood oxygen level dependent) fMRI signal contrast - insula; BOLD (Blood oxygen level dependent) fMRI signal contrast - dACC.
Enrollment: 207 participants.
How strong is the evidence?
Evidence Hub reads this as a clinical trial, done in people. Its evidence level is 3 of 5 (Moderate · trial / cohort / secondary analysis). Trials without a large randomized design, cohorts and secondary analyses give moderate evidence. Reported size: 207 participants or records.
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