Evaluation of in vitro activity of delafloxacin against Staphylococcus aureus MSSA and MRSA isolated from a Brazilian tertiary hospital
Abstract
Introduction: Proper treatment for infections caused by Staphylococcus aureus, particularly methicillin-resistant strains (MRSA), remains a constant challenge in hospital settings. In this context, the search for new antimicrobials, such as delafloxacin, has become necessary. Delafloxacin is a novel quinolone with a broad spectrum of activity against both gram-positive and gram-negative bacteria, offering a new therapeutic option for the treatment of infections caused by multidrug-resistant bacteria.
Materials and methods: 117 S. aureus isolates were included in this study: 48 S. aureus methicillin-susceptible (MSSA) and 69 S. aureus methicillin-resistant (MRSA). Isolates were recovered from skin and soft tissue sites, respiratory tract, and blood cultures. Delafloxacin susceptibility was assessed using the gradient diffusion strip (Liofilchem®), and the results were interpreted according to the BrCAST guidelines. To assess the clonal profile of S. aureus, Fourier-transform infrared (FTIR) spectroscopy was employed using the IR Biotyper system.
Results: Susceptibility to delafloxacin varied from 97.8% to 54.7% for isolates from skin/soft tissue and from respiratory tract, respectively. Blood culture isolates exhibited a Minimum Inhibitory Concentration (MIC) ≤ 0.5 mg/L. FTIR analysis using the IR Biotyper indicated a diverse distribution among the isolates.
Discussion: Due to the high sensitivity rates found in this study, delafloxacin may be considered as a good therapeutic…
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