Epidemiological characterization of uveitis in the elderly population: a systematic review and meta-analysis
Abstract
Purpose: This systematic review and meta-analysis aimed to characterize etiological patterns of uveitis in individuals aged 60 years or older.
Methods: Following the PRISMA 2020 and MOOSE reporting guidelines, we searched PubMed/MEDLINE, Scopus, PubMed Central (PMC), and Web of Science (January 1, 2005-January 1, 2025). Data extraction focused on study characteristics, sample size, uveitis location, and reported causes. Random-effects models were used to pool proportions across studies, heterogeneity assessed by the I2 statistic. Methodological quality was evaluated via the Newcastle-Ottawa Scale for cohort studies and the JBI Critical Appraisal Checklist for cross-sectional studies.
Results: Out of 10,829 retrieved citations, 16 studies met the inclusion criteria. Idiopathic uveitis constituted the largest proportion, with a pooled proportion of 41.45% (95% CI 30.63-53.16%). Infectious etiologies included herpetic uveitis (pooled proportion 11.40%, 95% CI 7.45-17.04%), cytomegalovirus (3.09%, 95% CI 1.01-9.06%) and tuberculosis (5.10%, 95% CI 2.58-9.83%). Non-infectious causes, such as sarcoidosis (5.21%, 95% CI 2.78-9.55%) and HLA-B27-associated uveitis (6.05%, 95% CI 3.35-10.71%), also contributed substantially. High heterogeneity (I2 > 75%) was noted across most etiologies, likely reflecting variable study populations, diagnostic criteria, and geographic factors.
Conclusion: Our meta-analysis underscores the diverse etiological landscape of uveitis in the elderly, with…
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid.
Read the paper
Related studies
- Understanding the factors influencing fall armyworm (Spodoptera frugiperda J.E. Smith) damage in African smallholder maize fields and quantifying its impact on yield. A case study in Eastern Zimbabwe
- Alarming situation of emerging H5 and H7 avian influenza and effective control strategies
- Livestock and food security: vulnerability to population growth and climate change
- Atmosphere–ocean oxygen and productivity dynamics during early animal radiations
- Characterization of the global distribution and diversified plasmid reservoirs of the colistin resistance gene mcr-9
- The global seroprevalence of Toxoplasma gondii in pigs: A systematic review and meta-analysis
Go deeper in Evidence Hub
Evidence Hub adds a study data sheet (design, sample size, evidence level, key numbers), an AI summary and a chat grounded in the paper's text.