Regional, age-specific and sex-specific trends in the prevalence of overweight or obesity in type 1 diabetes from 1980 to 2020: a meta-analysis of 78 observational studies with 650,265 participants
Abstract
Aims: To investigate the temporal trends in the overweight or obesity prevalence among people with type 1 diabetes (T1D).
Methods: PubMed, Embase, and Cochrane were searched for observational studies reporting the prevalence of overweight or obesity in T1D from the inception to March 2024. The pooled prevalence was calculated in random-effect model.
Results: This meta-analysis incorporated 78 studies with 650,265 participants. Among adults with T1D, the prevalence of obesity increased from 3.3% [95%CI:2.1-5.0] during 1985-1990 to 23.7% [95%CI:17.9-30.1] during 2015-2020. The prevalence of overweight exhibited a sustained upward trajectory, reaching 31.4% [95%CI:25.6-37.5] by 2015-2020 for adults with T1D. In children and adolescents with T1D, the prevalence of obesity rose from 6.3% [95%CI:3.8-9.8] to 12.2% [95%CI:7.2-18.3] during 1990-2010, declining modestly to 9.3% [95%CI:6.7-12.4] during 2010-2020. The prevalence of overweight maintained approximately 20% over two decades for children and adolescence with T1D. Obesity prevalence increased in both sexes, and people living in North America might exhibit the highest obesity prevalence across continents.
Conclusions: The overweight or obesity prevalence has been increasing in T1D during 1980-2020, which may contribute to the increased risk of the diabetic complications, especially cardiovascular diseases. Weight management may be one of unmet clinical needs for future T1D management.
How strong is the evidence?
Evidence Hub reads this as a meta-analysis, done in people. Its evidence level is 1 of 5 (Highest · pooled evidence). Pooled evidence from several studies sits at the top of the evidence pyramid. Reported size: 650,265 participants or records.
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